Endocrine Abstracts

The genetic heterogeneity of pheochromocytomas and paragangliomas (PPGL) offers opportunities to develop individualized treatment approaches for affected patients. Therefore, an improved understanding of the molecular features associated with different tumor phenotypes is required. Hypoxia-inducible factor (HIF) 2α-regulated pathways involving the MYC/MAX complex are directly linked to differentiation and aggressiveness in PPGLs. However, the distinct functions of the two...